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Information collected : Name, Phone number, E-mail, Message
Purpose of collection and use : conducting certain services or activities including but not limited to replying to inquiries and maintaining business records.
Period of retention and use : Personal information is to be discarded after the purpose of collection and use has been achieved.

- Personal Information shall be discarded without delay once the purpose of collection and use has been achieved; provided however that, if an obligation to retain such information exists under applicable law(s), the information shall be retained for a period of time as required by such law(s).
- Even prior to the purpose of use and collection being achieved, personal information may be discarded upon request via email sent to olixpharma@olixpharma.com. Please note, however, that your use of the services herein may be limited.

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Platform Technology

RNAi platform development

Lead compound discovery

Pulmonology / Neurology

Pharmacological research on OliX RNAi compounds for respiratory and neurological diseases

Ophthalmology

Pharmacological research on OliX RNAi compounds for ocular diseases

Animal Research

Testing efficacy of oligonucleotide therapeutics using animal models

Analytics

Develop analytical methods for therapeutic candidates to determine purity and stability in support of nonclinical and clinical studies

PK/TK

Develop bioanalytical methods to quantitate therapeutic candidates in biological matrices for pharmacokinetic and toxicokinetic (PK/TK) studies

CMC

Manage manufacturing, analytics and quality of therapeutic candidates

Toxicology

Conduct safety evaluation and toxicokinetic assessment of therapeutic candidates through nonclinical studies

Clinical

Establish clinical development plans for therapeutic candidates and conduct clinical studies

Management

Business Management

Purchasing

General Affairs

Facility Management

Contingency Planning

Planning

Budget/Performance Management

Mid to Long-term Business Goals/Strategy Planning

Accounting & Finance

Make official announcements about business contents, financial condition, business performance etc.

Stabilize Internal Accounting Control System

IT

IT Infrastructure Management

IT Helpdesk

Human Resources

HR Policy/System Establishment, Organization/Job Design

Recruitment/HR Management

Performance Management, Employee Welfare

HR Development

Legal Affairs

Prevent, respond, handle legal disputes

Provide risk management and compliance support

Develop IP strategies for core technologies

Quality Assurance(QA)

Verify pharmaceutical R&D processes and results

Ensure product to meet the established quality standards

Business Development

Develop/Maintain Client Relationships

Execute Licensing Agreements

New Business/Strategy Planning

Communications

Provide investment information in a timely manner to increase company value

Promote management activities and establish internal/external communication strategies

Create positive corporate culture through various in-house activities and employee education

Home
R&D

R&D

OliX Pipeline

OliX Pipeline

Pipeline
OLX101A
OLX104C
OLX301A
OLX301D
OLX702A
OLX703A

OLX703A

Hepatitis B Treatment

OLX703A targets a sequence that is common to all viral transcripts of hepatitis B virus (HBV),
with the aim of reducing serum levels of HBV surface antigen.
It also has the advantage of targeting sequences that are conserved in over 90% of 10 genotypes,
making the drug applicable to a diverse range of patients, including those resistant to existing antiviral drugs.

Target RNA: HBV transcripts

Administration Route: Subcutaneous Injection

Hepatitis B

Hepatitis B, a type of viral hepatitis, is transmitted through blood or body fluids. When a cell is infected, it triggers an immune response to eliminate the virus, often causing liver inflammation. The process can lead to cirrhosis and, ultimately, liver cancer. The viral genome is stored in infected liver cells as cccDNA (covalently closed circular DNA), in which the disease can persist chronically even after antiviral treatment.

Preclinical Data

Development Status

Efficacy verified in AAV-HBV mouse model

Conference Presentation

2021 OTS (Oligonucleotide Therapeutics Society) (21.09)