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Purpose of collection and use : conducting certain services or activities including but not limited to replying to inquiries and maintaining business records.
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Platform Technology

RNAi platform development

Lead compound discovery

Pulmonology / Neurology

Pharmacological research on OliX RNAi compounds for respiratory and neurological diseases

Ophthalmology

Pharmacological research on OliX RNAi compounds for ocular diseases

Animal Research

Testing efficacy of oligonucleotide therapeutics using animal models

Analytics

Develop analytical methods for therapeutic candidates to determine purity and stability in support of nonclinical and clinical studies

PK/TK

Develop bioanalytical methods to quantitate therapeutic candidates in biological matrices for pharmacokinetic and toxicokinetic (PK/TK) studies

CMC

Manage manufacturing, analytics and quality of therapeutic candidates

Toxicology

Conduct safety evaluation and toxicokinetic assessment of therapeutic candidates through nonclinical studies

Clinical

Establish clinical development plans for therapeutic candidates and conduct clinical studies

Management

Business Management

Purchasing

General Affairs

Facility Management

Contingency Planning

Planning

Budget/Performance Management

Mid to Long-term Business Goals/Strategy Planning

Accounting & Finance

Make official announcements about business contents, financial condition, business performance etc.

Stabilize Internal Accounting Control System

IT

IT Infrastructure Management

IT Helpdesk

Human Resources

HR Policy/System Establishment, Organization/Job Design

Recruitment/HR Management

Performance Management, Employee Welfare

HR Development

Legal Affairs

Prevent, respond, handle legal disputes

Provide risk management and compliance support

Develop IP strategies for core technologies

Quality Assurance(QA)

Verify pharmaceutical R&D processes and results

Ensure product to meet the established quality standards

Business Development

Develop/Maintain Client Relationships

Execute Licensing Agreements

New Business/Strategy Planning

Communications

Provide investment information in a timely manner to increase company value

Promote management activities and establish internal/external communication strategies

Create positive corporate culture through various in-house activities and employee education

Home
R&D

R&D

OliX Pipeline

OliX Pipeline

Pipeline
OLX101A
OLX104C
OLX301A
OLX301D
OLX702A
OLX703A

OLX702A

NASH Treatment

OliX’s robust nonalcoholic hepatitis (NASH) program, OLX702A, targets a gene stemming from genome-wide association studies (GWAS). In addition to improving the fatty liver, hepatic steatosis, and fibrosis, OliX is expanding the drug indication to obesity. NASH is the most common liver disease worldwide with no treatment, giving it promising market potential.

* GWAS: This is a study analyzing the correlation between the specific disease and the nucleic sequence, conducted on a large-scale population of 450,000 individuals. It provides statistically significant genetic data.

Target RNA: Undisclosed

Administration Route: Subcutaneous Injection

Non-alcoholic Steatohepatitis (NASH)

NASH is a liver condition characterized by the accumulation of liver fat, inflammation, and hepatocellular damage, regardless of heavy alcohol use. If left untreated, the condition can aggravate to cause fibrosis, cirrhosis, and even liver cancer. NASH often coexists with other metabolic disorders such as obesity, diabetes, and dyslipidemia. While liver fibrosis was considered irreversible, recent studies suggest that robust therapeutics may revert fibrous tissues to normal.

Preclinical Data

Development Status

Excellent efficacy in NASH/Fibrosis mouse model
Efficacy verified in NASH NHP model
Plan to file IND, 2023

Conference Presentation

2021 OTS (Oligonucleotide Therapeutics Society) (21.09)
2022 OTS (Oligonucleotide Therapeutics Society) (22.10)