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Platform Technology

RNAi platform development

Lead compound discovery

Pulmonology / Neurology

Pharmacological research on OliX RNAi compounds for respiratory and neurological diseases

Ophthalmology

Pharmacological research on OliX RNAi compounds for ocular diseases

Animal Research

Testing efficacy of oligonucleotide therapeutics using animal models

Analytics

Develop analytical methods for therapeutic candidates to determine purity and stability in support of nonclinical and clinical studies

PK/TK

Develop bioanalytical methods to quantitate therapeutic candidates in biological matrices for pharmacokinetic and toxicokinetic (PK/TK) studies

CMC

Manage manufacturing, analytics and quality of therapeutic candidates

Toxicology

Conduct safety evaluation and toxicokinetic assessment of therapeutic candidates through nonclinical studies

Clinical

Establish clinical development plans for therapeutic candidates and conduct clinical studies

Management

Business Management

Purchasing

General Affairs

Facility Management

Contingency Planning

Planning

Budget/Performance Management

Mid to Long-term Business Goals/Strategy Planning

Accounting & Finance

Make official announcements about business contents, financial condition, business performance etc.

Stabilize Internal Accounting Control System

IT

IT Infrastructure Management

IT Helpdesk

Human Resources

HR Policy/System Establishment, Organization/Job Design

Recruitment/HR Management

Performance Management, Employee Welfare

HR Development

Legal Affairs

Prevent, respond, handle legal disputes

Provide risk management and compliance support

Develop IP strategies for core technologies

Quality Assurance(QA)

Verify pharmaceutical R&D processes and results

Ensure product to meet the established quality standards

Business Development

Develop/Maintain Client Relationships

Execute Licensing Agreements

New Business/Strategy Planning

Communications

Provide investment information in a timely manner to increase company value

Promote management activities and establish internal/external communication strategies

Create positive corporate culture through various in-house activities and employee education

Home
R&D

R&D

OliX Pipeline

OliX Pipeline

Pipeline
OLX101A
OLX104C
OLX301A
OLX301D
OLX702A
OLX703A

OLX301D

Subretinal Fibrosis / wet AMD Treatment

OLX301D is designed to target CTGF mRNA and inhibits the progression of subretinal fibrosis and neovascularization.
Many times, subretinal fibrosis is the direct cause of vision loss. As there are no approved drugs and the therapeutics is expected to
be effective in approximately 30% of wet AMD patients who do not respond to anti-VEGF treatments,
the program is expected to address a significant portion of unmet needs once developed.

* CTGF(Connective Tissue Growth Factor): a protein regulating proliferation and tissue repair

* VEGF(Vascular Endothelial Growth Factor): a signal protein stimulating the formation of new blood vessels

Target RNA: CTGF

Administration Route: Intravitreal Injection

Subretinal Fibrosis (SRF)

Subretinal fibrosis, which occurs in most cases of wet AMD, is known as the leading cause of irreversible vision loss. During neovascularization, fibrosis occurs along with local destruction of the RPE and choroidal vessels, permanently impairing the macula.

Preclinical Data

Development Status

Expanded License and Collaboration Agreement with Théa Open Innovation (Territory: Worldwide excl. Asia-Pacific) (20.10)
Efficacy identified in animal models with SRF and wet AMD
Confirmation of superior synergistic efficacy with conventional anti-VEGF treatment

Conference Presentation

2021 CSHL(Cold Spring Harbor Laboratory)-Nucleic Acid Therapies (21.03)
2021 OTS (Oligonucleotide Therapeutics Society) (21.09)