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Platform Technology

RNAi platform development

Lead compound discovery

Pulmonology / Neurology

Pharmacological research on OliX RNAi compounds for respiratory and neurological diseases

Ophthalmology

Pharmacological research on OliX RNAi compounds for ocular diseases

Animal Research

Testing efficacy of oligonucleotide therapeutics using animal models

Analytics

Develop analytical methods for therapeutic candidates to determine purity and stability in support of nonclinical and clinical studies

PK/TK

Develop bioanalytical methods to quantitate therapeutic candidates in biological matrices for pharmacokinetic and toxicokinetic (PK/TK) studies

CMC

Manage manufacturing, analytics and quality of therapeutic candidates

Toxicology

Conduct safety evaluation and toxicokinetic assessment of therapeutic candidates through nonclinical studies

Clinical

Establish clinical development plans for therapeutic candidates and conduct clinical studies

Management

Business Management

Purchasing

General Affairs

Facility Management

Contingency Planning

Planning

Budget/Performance Management

Mid to Long-term Business Goals/Strategy Planning

Accounting & Finance

Make official announcements about business contents, financial condition, business performance etc.

Stabilize Internal Accounting Control System

IT

IT Infrastructure Management

IT Helpdesk

Human Resources

HR Policy/System Establishment, Organization/Job Design

Recruitment/HR Management

Performance Management, Employee Welfare

HR Development

Legal Affairs

Prevent, respond, handle legal disputes

Provide risk management and compliance support

Develop IP strategies for core technologies

Quality Assurance(QA)

Verify pharmaceutical R&D processes and results

Ensure product to meet the established quality standards

Business Development

Develop/Maintain Client Relationships

Execute Licensing Agreements

New Business/Strategy Planning

Communications

Provide investment information in a timely manner to increase company value

Promote management activities and establish internal/external communication strategies

Create positive corporate culture through various in-house activities and employee education

Home
R&D

R&D

OliX Pipeline

OliX Pipeline

Pipeline
OLX101A
OLX201A
OLX301A
OLX301D

Idiopathic Pulmonary Fibrosis (IPF)

• Scarring of lung tissue is a chronic, irreversible and fatal disease

• Symptoms: chronic dry, hacking cough; fatigue and weakness; discomfort in the chest; loss of appetite; unexplained weight loss

• Currently, there is no cost-effective therapeutics for the IPF

Market Potential

• The number of IPF patients in the EU is estimated to be about 80,000~110,000. Approximately 30,000~35,000 new patients are emerging every year (Source : European IPF Charter)

• Annual Potential IPF market: $900M in 2015 By 2025, expected to grow to $3.2B (Source : GlobalData Healthcare 2016)

Government Funding

• A*STAR(Singapore)-KHIDI(Korea) Joint Grant Call: $1.8M / 3 years (2014.10~2017.09)
* KHIDI: Korea Health Industry Development Institute (www.khidi.or.kr)

Development Status

• Outstanding efficacy identified from animal models