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Platform Technology

RNAi platform development

Lead compound discovery

Pulmonology / Neurology

Pharmacological research on OliX RNAi compounds for respiratory and neurological diseases

Ophthalmology

Pharmacological research on OliX RNAi compounds for ocular diseases

Animal Research

Testing efficacy of oligonucleotide therapeutics using animal models

Analytics

Develop analytical methods for therapeutic candidates to determine purity and stability in support of nonclinical and clinical studies

PK/TK

Develop bioanalytical methods to quantitate therapeutic candidates in biological matrices for pharmacokinetic and toxicokinetic (PK/TK) studies

CMC

Manage manufacturing, analytics and quality of therapeutic candidates

Toxicology

Conduct safety evaluation and toxicokinetic assessment of therapeutic candidates through nonclinical studies

Clinical

Establish clinical development plans for therapeutic candidates and conduct clinical studies

Management

Business Management

Purchasing

General Affairs

Facility Management

Contingency Planning

Planning

Budget/Performance Management

Mid to Long-term Business Goals/Strategy Planning

Accounting & Finance

Make official announcements about business contents, financial condition, business performance etc.

Stabilize Internal Accounting Control System

IT

IT Infrastructure Management

IT Helpdesk

Human Resources

HR Policy/System Establishment, Organization/Job Design

Recruitment/HR Management

Performance Management, Employee Welfare

HR Development

Legal Affairs

Prevent, respond, handle legal disputes

Provide risk management and compliance support

Develop IP strategies for core technologies

Quality Assurance(QA)

Verify pharmaceutical R&D processes and results

Ensure product to meet the established quality standards

Business Development

Develop/Maintain Client Relationships

Execute Licensing Agreements

New Business/Strategy Planning

Communications

Provide investment information in a timely manner to increase company value

Promote management activities and establish internal/external communication strategies

Create positive corporate culture through various in-house activities and employee education

Home
R&D

R&D

OliX Pipeline

OliX Pipeline

Pipeline
OLX101A
OLX104C
OLX301A
OLX301D
OLX702A
OLX703A

OLX104C

Androgenic Alopecia Treatment

OLX104C is developed to delay the progression of androgenic alopecia by inhibiting the expression of androgen receptors (AR).
The therapeutics is expected to have high commercial value as it demonstrates long-term efficacy while minimizing side effects of existing drugs such as sexual dysfunction and restricted use on women.

Target RNA: Androgen Receptor (AR)

Administration Route: Intradermal Injection

Androgenic Alopecia (AGA)

Androgenic alopecia results from male hormone response. Testosterone is converted into dihydrotestosterone (DHT) by 5-alpha reductase, and its binding with androgen receptors leads to reduced follicles to change in the hair growth cycle, ultimately causing hair growth to cease.

Preclinical Data

Development Status

Efficient inhibition of AGA identified in animal models and hair follicles
Patent granted (US, Japan, Korea)
Phase 1 clinical trial IND approved (Australia) (23.03)

Conference Presentation

2021 Korean Hair Research Society – Hair Forum (21.05)
2021 OTS (Oligonucleotide Therapeutics Society) (21.09)
2022 Molecular Pharmaceutics (22.11)