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OliX Asymmetric RNAi Triggering Molecules

OliX Asymmetric RNAi Triggering Molecules

asiRNA

  • Comparable potency, reduced non-specific effects
  • Patent : PCT/KR2008/007530     
    - Issued in Korea, Europe, Japan, Australia and China
    - Under review in USA

lasiRNA

  • Increased potency, reduced non-specific effects
  • Patent : PCT/KR2011/006632
    - Issued in Korea, Japan and USA
    - Under review in Europe, Canada

cp-asiRNA

  • Contains cell-penetrating moiety
  • Patent : PCT/KR2013/004463
    - Issued in Korea
    - Under review in USA, Europe, Japan and China

tiRNA

  • siRNA complex with increased cell penetrating capacity,
    multiple targets
  • Patent : PCT/KR2010/000678
    - Issued in Korea, Europe, Japan
    - Under review in USA

bg-asiRNA

  • Minimized side effects with bulge structure
  • Patent : PCT/KR2010/007771
    - Issued in Korea and USA

Publication related in OliX RNAi technology

  • Hwang, J., Chang, C., Kim, J. H., Oh, C. T., Lee, H. N., Lee, C., Oh, D., Lee, C., Kim, B., Hong, S. W., & Lee, D. K. (2016). Development of Cell-Penetrating Asymmetric Interfering RNA Targeting Connective Tissue Growth Factor. Journal of Investigative Dermatology, 136(11), 2305-2313.
  • Hong, S. W., Park, J. H., Yun, S., Lee, C. H., Shin, C., & Lee, D. K. (2014). Effect of the guide strand 3′-end structure on the gene-silencing potency of asymmetric siRNA. Biochemical Journal, 461(3), 427-434.
  • Chang, C., Hong, S. W., Dua, P., Kim, S., & Lee, D. K. (2013). The design, preparation, and evaluation of asymmetric small interfering RNA for specific gene silencing in mammalian cells. siRNA Design: Methods and Protocols, 135-152.
  • Jo, S. G., Hong, S. W., Yoo, J. W., Lee, C. H., Kim, S., Kim, S., & Lee, D. K. (2011). Selection and optimization of asymmetric siRNA targeting the human c-MET gene. Molecules and cells, 32(6), 543-548.
  • Chang, C. I., Kim, H. A., Dua, P., Kim, S., Li, C. J., & Lee, D. K. (2011). Structural diversity repertoire of gene silencing small interfering RNAs. Nucleic acid therapeutics, 21(3), 125-131.
  • Chang, C. I., Yoo, J. W., Hong, S. W., Lee, S. E., Kang, H. S., Sun, X., Rogoff, H. A., Ban, C., Kim, S., Li, C. J., & Lee, D. K. (2009). Asymmetric shorter-duplex siRNA structures trigger efficient gene silencing with reduced nonspecific effects. Molecular Therapy, 17(4), 725-732.
  • Kim Y, Kang YG, Choe JY, Lee D, Shin C, Hong SW, Lee DK (2018) RNA Interference-Mediated Gene Silencing by Branched Tripodal RNAs Does Not Require Dicer Processing, Nucleic Acid Therapeutics,28(1):44-49