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asiRNA

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Asymmetric siRNA
(asiRNA)

Asymmetric siRNA (asiRNA) is a unique gene silencing technology developed byOliX based on RNA interference (RNAi) which is by far the most efficient gene regulation technology.

Because of the unprecedented potential for curing various diseases (including genetic disorders, cancer, and viral infection), gene silencing technology via RNAi has been drawing a lot of attention by academia as well as industry, including global pharmaceutical companies.

However, several studies reported that, the small interfering RNA (siRNA) currently used for RNAi drug development, could trigger various side effects including off-target gene silencing, immune stimulation, and saturation of the endogenous RNAi machinery. Some of these side effects resulted in delay or even termination of RNAi therapeutic programs.

asiRNA not only shows comparable gene silencing compared with conventional siRNA, but also significantly reduces siRNA-mediated side effects such as off-target gene silencing and immune stimulation. Because safe and specific gene silencing can be achieved by asiRNA, we believe that asiRNA is the next generation RNAi trigger for therapeutic development.

Publication

  • Chang et al. Molecular Therapy 17, 725-732 (2009) [featured article]

Patent

  • “Novel siRNA Structure for Minimizing Off-target Effects and Relaxing Saturation of RNAi Machinery and the Use Thereof”
    (PCT/KR2008/007530)
    Issued in Korea, Europe, Japan, Australia and China
    Under review in USA
  • “Nucleic acid molecule which induces RNA interference and its use”
    (PCT/KR2011/006632)
    Issued in Korea, Japan and USA
    Under review in Europe, China and Canada